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Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Caution should be used in the elderly because paroxetine is the most sedating and anticholinergic of the selective serotonin reuptake inhibitors The elderly are prone to SSRI/SNRI-induced hyponatremia; monitor closely 65 years In children and young adults, risks must be wehed against the benefits of taking antidepressants Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during the initial 1-2 months of therapy and dosage adjustments The patient’s family should communicate any abrupt changes in behavior to the healthcare provider Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy This drug is not approved for use in pediatric patients Clinical worsening and suicidal ideation may occur despite medication in adolescents and young adults (18-24 years) Use caution in patients with bipolar disorder, seizure disorder, history of suicidal thought/behavior Risk of mydriasis; may trger angle closure attack in patients with angle closure glaucoma with anatomiy narrow angles without a patent iridectomy Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) Risk of complications such as feeding difficulties, irritability, and respiratory problems reported in neonates exposed to SNRIs/SSRIs late in third trimester Risk of cardiovascular defects in infants whose mothers took drug during early pregnancy Withdraw gradually Use lower starting dose in renal impairment (Cr Cl Pregnancy category: D Teratogenic effects: Epidemiologic studies have shown that infants exposed to paroxetine in the first trimester of pregnancy have an increased risk of congenital malformations, particularly cardiovascular malformations Use late in the third trimester associated with complications in newborns and may require prolonged hospitalization, respiratory support, and tube feeding A study of nearly 28,000 women taking SSRIs confirmed 5 previously reported birth defercts associated with paroxetine, including heart defects, anencephaly, and abdominal wall defects (BMJ 2015; 351:h3190) Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use, and it displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers (PMs) CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) that in addition to being substrates for CYP2D6, are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only.

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Six-Month-Old Grace Scholl looks at her mom Anna Scholl Monday October 11, 2010 in their Cedar Rapids home. Believe it or not, stomach acid isn’t there just to punish you for eating Indian food.

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When you’re considering medication for a child with emotional or behavioral problems, how you start is very important. With most psychoactive medications it’s important to taper off gradually rather than stopping quickly. From April 2013 to March 2014, sales of Abilify amounted to almost .9 billion.

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Objective To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. Setting Patients registered with UK general practices contributing data to the QResearch database. Aka Oleptro, Beneficat, Deprax, Desirel, Molipaxin, Thombran, Trazorel, Trialodine, Trittico, and Mesyrel Trazodone (trazodone hydrocoride) is a nasty drug often added to antidepressants and other "activating" drugs to aid sleep.

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February 2012, just six weeks after the grounding of the Costa Concordia the vessels sister ship Costa Allegra was cast adrift in the Indian Ocean and had to be towed to safety. A sister ship is generally defined as a “a ship of the same class as, or of virtually identical desn to, another ship.” To their credit, several newspapers have changed their headlines, no doubt after fact checkers pointed out that the two cruise ships are not anywhere close to being “sister ships.” Second cousins, perhaps. In 1986, she was sold to Antonis Lelakis, who planned on converting her to a cruise ship for Regency Cruises. She entered service as This entry was posted in Current, Lore of the Sea, Ships and tagged Annie Johnson III, Axel Johnson, container ship, Costa Allegra, Costa Concordia, Costa Marina, Rederi AB stjernan.