Alendronic acid - pedia Take only in morning, not at bedtime or before arising Take tablet with full glass of water (6-8 oz) at least 30 minutes before first food or drink of day, in uprht position Administer oral solution with at least 2 ounces of water Swallow with plain water only; mineral water, coffee, juice or other beverages severely reduces bioavailability Swallow tablet whole; do not suck or chew Do not lie down for 30 minutes after taking drug; sit or stand uprht Despite long terminal half-life (10 years), bone-incorporated drug is not pharmacologiy active If dietary intake is inadequate, patients should receive calcium supplement and vitamin D Hypophosphatemia, transient and mild (10%) Abdominal pain (7%) Musculoskeletal pain (4.1%) Dyspepsia (3.6%) Nausea (3.6%) Constipation (3.1%) Diarrhea (3.1%) Flatulence (2.6%) Headache (2.6%) Acid regurgitation (2%) Esophagitis (1.5%) Abdominal distention (1%) Body as a whole: Hypersensitivity reactions including urticaria and angioedema; transient myalgia, malaise, asthenia, and fever; symptomatic hypocalcemia; peripheral edema Gastrointestinal: Esophagitis, esophageal erosions, esophageal ulcers, esophageal stricture or perforation, and oropharyngeal ulceration; gastric or duodenal ulcers Localized osteonecrosis of the jaw, generally associated with tooth extraction and/or local infection with delayed healing Musculoskeletal: Bone, joint, and/or muscle pain, occasionally severe, and incapacitating; joint swelling; low-energy femoral shaft and subtrochanteric fractures Nervous system: dizziness, verto Pulmonary: Acute asthma exacerbations Skin: Rash (occasionally with photosensitivity), pruritus, alopecia, severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis Special Senses: Uveitis, scleritis, or episcleritis, cholesteatoma of the external auditory canal (focal osteonecrosis) May cause local irritation of upper GI mucosa Take with plain water only, not coffee, juice, or mineral water; sit or stand uprht for at least 30 minutes after administration Hypocalcemia reported with use of bisphosphonates; correct hypocalcemia prior to therapy; ensure adequate calcium and vitamin D intake Conjunctivitis, uveitis, episcleritis, and scleritis reported with alendronate use; perform ophthalmic evaluation in patients with sns of ocular inflammation Avoid concomitant polyvalent cation-containing medications Osteonecrosis of the jaw, can occur spontaneously and is generally associated with tooth extraction and/or local infection with delayed healing; known risk factors include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders; risk of osteonecrosis of the jaw may increase with duration of exposure to bisphosphonates Not recommended in severe renal impairment (Cr Cl The above information is provided for general informational and educational purposes only. Alendronic acid INN or alendronate sodium USAN — sold as Fosamax by Merck — is a bisphosphonate drug used for osteoporosis. 4 Uses; 5 Contraindications and precautions; 6 Side-effects; 7 Interactions; 8 Dosage; 9 Dosage forms.
Indications and usage Individual plans may vary and formulary information changes. Other beverages including mineral water, food, and some medications are likely to reduce the absorption of FOSAMAX see Drug Interactions 7.1.
ALENDRONATE - ORAL Fosamax side effects, medical A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. Consumer information about the medication ALENDRONATE - ORAL Fosamax, includes side effects, drug interactions, recommended dosages, and storage information.
Fosomax drug interactions:
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